Tau Protein Alzheimer's ~ Definition: Overview Research Papers on Tau Protein Alzheimer's

Tau Protein Alzheimer's ~ Definition: Overview Research Papers on Tau Protein Alzheimer's

Tau Protein Definition-I: A protein found in the axons of healthy neurons, where it binds to other proteins called microtubules to form the cytoskeleton of the neuron and provide the tracks over which material can be transported from one part of the neuron to another. http://www.answers.com/topic/tau-protein#ixzz1Vx45TwC7

Tau Protein Definition-II

(Biochemistry) a protein that maintains the stability of the microtubules that serve as a transport system within brain cells. It is also implicated in the formation of masses of fibrous protein in the brains of people with Alzheimer’s disease. http://www.science-dictionary.com/definition/tau-protein.html

Tau Protein Definition-III

A microtubule-associated protein that forms insoluble and hyperphosphorylated aggregates in Alzheimer's disease. http://medical-dictionary.thefreedictionary.com/tau+protein

Tau Protein Definition-IV 

(Science: cell biology) protein (60-70 kD) that co purifies with tubulin through cycles of assembly and disassembly and the first microtubule associated protein to be characterised. Tau proteins are a family made by alternative splicing of a single gene. It has tandem repeats of a tubulin binding domain and promotes tubulin assembly. Although tau proteins are found in all cells they are major components of neurons where they are predominantly associated with microtubules of the axon. http://www.biology-online.org/dictionary/Tau_protein

Tau Protein Definition-V 

Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES). http://medconditions.net/tau-protein.html

Research Papers on Tau Protein Alzheimer's

The Use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: A Retrospective Analysis.

Jung K, Goerdt C, Lange P, Blocher J, Djukic M, Gerber J, Spreer A, Nau R, Otto M, Schmidt H.

Eur Neurol. 2011 Aug 25;66(3):128-132. [Epub ahead of print]

Insulin-induced neurite-like process outgrowth: Acceleration of tau protein synthesis via a phosphoinositide 3-kinase∼mammalian target of rapamycin pathway.

Nemoto T, Yanagita T, Satoh S, Maruta T, Kanai T, Murakami M, Wada A.

Neurochem Int. 2011 Aug 9.

Tau Protein and Alzheimer's Disease.

Maccioni RB.

Curr Alzheimer Res. 2011 Aug 9.

[Involvement of Cdk5/p35 and tau protein in the hippocampal mossy fiber sprouting in the PTZ kindling model].

Tian FF, Guo TH, Dang J, Ma YF, Chen JM, Chen Y, Cai XF, Song MY.

Zhonghua Yi Xue Za Zhi. 2011 May 10;91(17):1197-202. Chinese.

A case of anti-GA1 antibody-positive Fisher syndrome with elevated tau protein in cerebrospinal fluid.

Oyazato Y, Shiihara T, Kusunoki S, Adachi M, Ohnishi N, Taniguchi H, Nishiyama A, Watanabe A, Kobayashi M, Kamioka I.

Brain Dev. 2011 Jul 8.

Increased levels of total tau protein in the cerebrospinal fluid in Huntington's disease.

Constantinescu R, Romer M, Zetterberg H, Rosengren L, Kieburtz K.

Parkinsonism Relat Disord. 2011 Jul 4.

Assessment of cerebrospinal fluid (CSF) beta-amyloid (1-42), phosphorylated tau (ptau-181) and totalTau protein in patients with Alzheimer's disease (AD) and other dementia at Siriraj Hospital, Thailand.

Thaweepoksomboon J, Senanarong V, Poungvarin N, Chakorn T, Siwasariyanon N, Washirutmangkur L, Udompunthuruk S.

J Med Assoc Thai. 2011 Feb;94 Suppl 1:S77-83.

The role of Tau protein in resistance to paclitaxel.

Smoter M, Bodnar L, Duchnowska R, Stec R, Grala B, Szczylik C.

Cancer Chemother Pharmacol. 2011 Sep;68(3):553-557. Epub 2011 Jun 29.

Tau Protein Assembles into Isoform- and Disulfide-dependent Polymorphic Fibrils with Distinct Structural Properties.

Furukawa Y, Kaneko K, Nukina N.

J Biol Chem. 2011 Aug 5;286(31):27236-46. Epub 2011 Jun 9.

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain.

Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM.

J Neurochem. 2011 Aug;118(4):658-67. doi: 10.1111/j.1471-4159.2011.07337.x. Epub 2011 Jul 1.

Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering.

Shkumatov AV, Chinnathambi S, Mandelkow E, Svergun DI.

Proteins. 2011 Jul;79(7):2122-31. doi: 10.1002/prot.23033. Epub 2011 May 10.

Synergistic interactions between repeats in tau protein and Aβ amyloids may be responsible for accelerated aggregation via polymorphic states.

Miller Y, Ma B, Nussinov R.

Biochemistry. 2011 Jun 14;50(23):5172-81. Epub 2011 May 18.

Use of cerebrospinal fluid amyloid-β and total tau protein to predict favorable surgical outcomes in patients with idiopathic normal pressure hydrocephalus.

Tarnaris A, Toma AK, Chapman MD, Keir G, Kitchen ND, Watkins LD.

J Neurosurg. 2011 Jul;115(1):145-50. Epub 2011 Mar 25.

Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.

Glöckner F, Meske V, Lütjohann D, Ohm TG.

J Neuropathol Exp Neurol. 2011 Apr;70(4):292-301.

Inhibition of phospholipase A(2) in rat brain decreases the levels of total Tau protein.

Schaeffer EL, De-Paula VJ, da Silva ER, de A Novaes B, Skaf HD, Forlenza OV, Gattaz WF.

J Neural Transm. 2011 Sep;118(9):1273-1279. Epub 2011 Mar 9.

Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease.

Noguchi-Shinohara M, Hamaguchi T, Nozaki I, Sakai K, Yamada M.

J Neurol. 2011 Aug;258(8):1464-8. Epub 2011 Mar 1.

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.

Smet-Nocca C, Broncel M, Wieruszeski JM, Tokarski C, Hanoulle X, Leroy A, Landrieu I, Rolando C, Lippens G, Hackenberger CP.

Mol Biosyst. 2011 May;7(5):1420-9. Epub 2011 Feb 16.

Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.

Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS.

J Am Chem Soc. 2011 Mar 9;133(9):3144-57. Epub 2011 Feb 14.

Local delivery of recombinant human bone morphogenetic protein-2 increases axonal regeneration and the expression of tau protein after facial nerve injury.

Wu G, Ju L, Jin T, Chen L, Shao L, Wang Y, Liu B.

J Int Med Res. 2010 Sep-Oct;38(5):1682-8.

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M.

J Neurosci. 2011 Feb 2;31(5):1688-92.

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Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.

Smet-Nocca C, Broncel M, Wieruszeski JM, Tokarski C, Hanoulle X, Leroy A, Landrieu I, Rolando C, Lippens G, Hackenberger CP.

Mol Biosyst. 2011 May;7(5):1420-9. Epub 2011 Feb 16.

PMID:

 

21327254

 

[PubMed - in process]

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18.

Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.

Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS.

J Am Chem Soc. 2011 Mar 9;133(9):3144-57. Epub 2011 Feb 14.

PMID:

 

21319744

 

[PubMed - indexed for MEDLINE] 

Free PMC Article

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19.

Local delivery of recombinant human bone morphogenetic protein-2 increases axonal regeneration and the expression of tau protein after facial nerve injury.

Wu G, Ju L, Jin T, Chen L, Shao L, Wang Y, Liu B.

J Int Med Res. 2010 Sep-Oct;38(5):1682-8.

PMID:

 

21309482

 

[PubMed - indexed for MEDLINE]

Related citations

20.

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M.

J Neurosci. 2011 Feb 2;31(5):1688-92.

PMID:

 

21289177

 

[PubMed - indexed for MEDLINE] 

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Tau Phosphorylation ~ Definition, Overview & Research Papers of Tau Phosphorylation ~ Tau Protein Blog

Tau Phosphorylation ~ Definition, Overview & Research Papers of Tau Phosphorylation ~ Tau Protein Blog

Tau phosphorylation and Alzheimer's disease

Tau protein forms the tangles that are one of the two recognisable features of Alzheimer’s disease morphology (the other being the amyloid plaques).

Phosphorylation and dephosphorylation are part of the normal processing tau undergoes in the healthy nerve cell in the brain. Tau protein can form the tangles that are observed in the brain of people with Alzheimer's disease following overproduction or over-phosphorylation. It has long been discussed whether the tangles are a secondary feature of the development of the disease or part of what causes the nerve cells to die.

Tau phosphorylation research

Professor Lu has identified an enzyme (Pin1), present in all types of cells, that assists in dephosphorylating tau. He and his colleagues have demonstrated a link between a decreased amount of this enzyme and the presence of tangles in post-mortem brain material from people with Alzheimer's disease. In order to further investigate the action of Pin1, Prof Lu developed a mouse strain engineered to not produce the Pin1 enzyme. These mice went on to develop Alzheimer's disease-like symptoms, age related tangles and neuronal cell death.

These results are very exciting because they provide the first mouse model for Alzheimer's disease that represent an under expression of a gene. It also supports the idea that over-phosphorylation of tau is an early event in the development of Alzheimer's disease.

Alzheimer's disease is likely to be a multi-factorial disease with the involvement of more than one gene and disease causing mechanism. More research is needed to work out the mechanism for this particular enzyme's action and to identify therapeutic targets.

This type of basic research on the causes of Alzheimer's disease is very important. It provides hope for people with Alzheimer's disease and their families that in the future it will be possible to treat the disease in earlier stages than is presently possible. http://alzheimers.org.uk/site/scripts/news_article.php?newsID=137

Tau Protein Definition-I: A protein found in the axons of healthy neurons, where it binds to other proteins called microtubules to form the cytoskeleton of the neuron and provide the tracks over which material can be transported from one part of the neuron to another. http://www.answers.com/topic/tau-protein#ixzz1Vx45TwC7

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.

Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK.

Neurobiol Aging. 2011 Aug 13. [Epub ahead of print]

The new indirubin derivative inhibitors of glycogen synthase kinase-3, 6-BIDECO and 6-BIMYEO, prevent tau phosphorylation and apoptosis induced by the inhibition of protein phosphatase-2A by okadaic acid in cultured neurons.

Martin L, Magnaudeix A, Wilson CM, Yardin C, Terro F.

J Neurosci Res. 2011 Aug 8. doi: 10.1002/jnr.22723. [Epub ahead of print]

Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation.

Hanger DP, Noble W.

Int J Alzheimers Dis. 2011;2011:352805. Epub 2011 Jul 11.

Lipopolysaccharide-induced tau phosphorylation and kinase activity - modulation, but not mediation, by corticotropin-releasing factor receptors.

Roe AD, Staup MA, Serrats J, Sawchenko PE, Rissman RA.

Eur J Neurosci. 2011 Aug;34(3):448-56. doi: 10.1111/j.1460-9568.2011.07764.x. Epub 2011 Jul 4.

Abnormal Tau Phosphorylation in the Thorny Excrescences of CA3 Hippocampal Neurons in Patients with Alzheimer's Disease.

Lidia BL, Virginia GM, Paula MS, Jesús A, Javier D.

J Alzheimers Dis. 2011 Jun 15. [Epub ahead of print]

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β.

Martin L, Page G, Terro F.

Neurochem Int. 2011 Aug;59(2):235-50. Epub 2011 Jun 6.

Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

Grueninger F, Bohrmann B, Christensen K, Graf M, Roth D, Czech C.

Mol Cell Biochem. 2011 Jun 3. [Epub ahead of print]

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W.

Cell Death Dis. 2011 Jun 2;2:e167.

Long-Term Overexpression of Heme Oxygenase 1 Promotes Tau Aggregation in Mouse Brain by Inducing Tau Phosphorylation.

Hui Y, Wang D, Li W, Zhang L, Jin J, Ma N, Zhou L, Nakajima O, Zhao W, Gao X.

J Alzheimers Dis. 2011 May 25. [Epub ahead of print]

β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites.

Frost D, Meechoovet B, Wang T, Gately S, Giorgetti M, Shcherbakova I, Dunckley T.

PLoS One. 2011 May 6;6(5):e19264.

Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells.

Taga M, Mouton-Liger F, Paquet C, Hugon J.

FEBS Lett. 2011 Jun 23;585(12):1801-6. Epub 2011 Apr 15.

Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation.

Reifert J, Hartung-Cranston D, Feinstein SC.

J Biol Chem. 2011 Jun 10;286(23):20797-811. Epub 2011 Apr 11.

Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine.

Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E.

Am J Pathol. 2011 Apr;178(4):1646-61.

Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways.

Hu JP, Xie JW, Wang CY, Wang T, Wang X, Wang SL, Teng WP, Wang ZY.

Brain Res Bull. 2011 May 30;85(3-4):194-200. Epub 2011 Mar 22.

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation.

Alon LT, Pietrokovski S, Barkan S, Avrahami L, Kaidanovich-Beilin O, Woodgett JR, Barnea A, Eldar-Finkelman H.

FEBS Lett. 2011 Apr 20;585(8):1158-62. Epub 2011 Mar 21.

Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress.

Zhang LF, Shi L, Liu H, Meng FT, Liu YJ, Wu HM, Du X, Zhou JN.

Int J Neuropsychopharmacol. 2011 Mar 22:1-12. [Epub ahead of print]

The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.

To AW, Ribe EM, Chuang TT, Schroeder JE, Lovestone S.

PLoS One. 2011 Feb 10;6(2):e16991.

Propofol directly increases tau phosphorylation.

Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, Morin F, Emala CW, Planel E.

PLoS One. 2011 Jan 31;6(1):e16648.

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain.

Qu Z, Jiao Z, Sun X, Zhao Y, Ren J, Xu G.

Brain Res. 2011 Apr 6;1383:300-6. Epub 2011 Jan 31.

The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.

Stieler JT, Bullmann T, Kohl F, Tøien Ø, Brückner MK, Härtig W, Barnes BM, Arendt T.

PLoS One. 2011 Jan 18;6(1):e14530.

Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons.

Zhang Z, Zhao R, Qi J, Wen S, Tang Y, Wang D.

J Neurosci Res. 2011 Mar;89(3):437-47. doi: 10.1002/jnr.22563. Epub 2010 Dec 17.

Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons.

Zhang Z, Zhao R, Tang Y, Wen S, Wang D, Qi J.

Neurochem Res. 2011 May;36(5):801-11. Epub 2011 Jan 18.

Overcoming cell death and tau phosphorylation mediated by PI3K-inhibition: a cell assay to measure neuroprotection.

Simon D, Medina M, Avila J, Wandosell F.

CNS Neurol Disord Drug Targets. 2011 Mar;10(2):208-14. Review.

Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons.

Zhang Z, Zhao R, Qi J, Wen S, Tang Y, Wang D.

J Neurosci Res. 2010 Dec 17. [Epub ahead of print]

Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3β pathway in ginsenoside Rb1's attenuation of beta-amyloid-induced neurotoxicity and tau phosphorylation.

Zhao R, Zhang Z, Song Y, Wang D, Qi J, Wen S.

J Ethnopharmacol. 2011 Feb 16;133(3):1109-16. Epub 2010 Dec 1.

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.

Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. Epub 2010 Nov 22.

Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone.

Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Cao FY, Wang Q, Wang JZ.

Neurochem Res. 2011 Feb;36(2):288-96.

Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.

Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J.

Brain Pathol. 2011 Mar;21(2):189-200. doi: 10.1111/j.1750-3639.2010.00437.x. Epub 2010 Oct 3.

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains.

Shi JQ, Shen W, Chen J, Wang BR, Zhong LL, Zhu YW, Zhu HQ, Zhang QQ, Zhang YD, Xu J.

Brain Res. 2011 Jan 12;1368:239-47. Epub 2010 Oct 21.

Tau phosphorylation and aggregation as a therapeutic target in tauopathies.

Badiola N, Suárez-Calvet M, Lleó A.

CNS Neurol Disord Drug Targets. 2010 Dec;9(6):727-40. Review.

Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.

Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S.

J Mol Neurosci. 2011 Mar;43(3):326-32. Epub 2010 Sep 14.

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.

Zempel H, Thies E, Mandelkow E, Mandelkow EM.

J Neurosci. 2010 Sep 8;30(36):11938-50.

Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice.

Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D.

Crit Care Med. 2010 Nov;38(11):2190-8.

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway.

Marwarha G, Dasari B, Prabhakara JP, Schommer J, Ghribi O.

J Neurochem. 2010 Oct;115(2):373-84. doi: 10.1111/j.1471-4159.2010.06929.x. Epub 2010 Aug 25.

Tau phosphorylation in hippocampus results in toxic gain-of-function.

Avila J, Gómez de Barreda E, Engel T, Lucas JJ, Hernández F.

Biochem Soc Trans. 2010 Aug;38(4):977-80. Review.

From tau phosphorylation to tau aggregation: what about neuronal death?

Buée L, Troquier L, Burnouf S, Belarbi K, Van der Jeugd A, Ahmed T, Fernandez-Gomez F, Caillierez R, Grosjean ME, Begard S, Barbot B, Demeyer D, Obriot H, Brion I, Buée-Scherrer V, Maurage CA, Balschun D, D'hooge R, Hamdane M, Blum D, Sergeant N.

Biochem Soc Trans. 2010 Aug;38(4):967-72. Review.

Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells.

Yoon SY, Park JS, Choi JE, Choi JM, Lee WJ, Kim SW, Kim DH.

Neurobiol Dis. 2010 Nov;40(2):449-55. Epub 2010 Jul 22.

The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.

Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H, Zhang YW.

Hum Mol Genet. 2010 Oct 1;19(19):3835-43. Epub 2010 Jul 22.

Ghrelin modulates insulin sensitivity and tau phosphorylation in high glucose-induced hippocampal neurons.

Chen Y, Cao CP, Li CR, Wang W, Zhang D, Han LL, Zhang XQ, Kim A, Kim S, Liu GL.

Biol Pharm Bull. 2010;33(7):1165-9.

Unilateral amyloid-beta25-35 injection into the rat amygdala increases the expressions of aberrant tau phosphorylation kinases.

Huang J, Chen YJ, Bian WH, Yu J, Zhao YW, Liu XY.

Chin Med J (Engl). 2010 May 20;123(10):1311-4.

Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure.

Li N, Yu ZL, Wang L, Zheng YT, Jia JX, Wang Q, Zhu MJ, Liu XL, Xia X, Li WJ.

Acta Biol Hung. 2010 Jun;61(2):123-34.

Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices.

Allyson J, Dontigny E, Auberson Y, Cyr M, Massicotte G.

Neural Plast. 2010;2010:340168. Epub 2010 May 20.

Molecular and cellular events of dopamine D1 receptor-mediated tau phosphorylation in SK-N-MC cells.

Lebel M, Cyr M.

Synapse. 2011 Jan;65(1):69-76. doi: 10.1002/syn.20818.

Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.

Nemoto T, Miyazaki S, Kanai T, Maruta T, Satoh S, Yoshikawa N, Yanagita T, Wada A.

Eur J Pharmacol. 2010 Aug 25;640(1-3):20-8. Epub 2010 May 12.

Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner.

Zhang Z, Simpkins JW.

Brain Res. 2010 Jul 23;1345:176-81. Epub 2010 May 7.

The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.

Bertrand J, Plouffe V, Sénéchal P, Leclerc N.

Neuroscience. 2010 Jun 30;168(2):323-34. Epub 2010 Apr 13.

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H.

J Neurosci. 2010 Apr 7;30(14):4845-56.

Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats.

Deng J, Shen C, Wang YJ, Zhang M, Li J, Xu ZQ, Gao CY, Fang CQ, Zhou HD.

Eur J Pharmacol. 2010 Jul 10;637(1-3):83-8. Epub 2010 Apr 2.

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.

Qian W, Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F.

J Alzheimers Dis. 2010;19(4):1221-9.

Abnormal tau phosphorylation in primary progressive multiple sclerosis.

Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S.

Acta Neuropathol. 2010 May;119(5):591-600. Epub 2010 Mar 21.